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Cell isolation and recovery using glass bubble

2024-01-05 17:10:44 115

Isolating and recovering cells using glass bubbles involves a process where glass microbubbles or glass bubbles are utilized as carriers or supports to aid in the separation and isolation of specific cells from a biological sample. This technique is often applied in cell sorting, separation, and isolation procedures in laboratory settings and biotechnological research.

The process typically involves the following steps:

  1. Functionalization of Glass Bubbles: The surface of the glass bubbles can be modified or functionalized with specific ligands, antibodies, or biomolecules that have an affinity for the target cells. This functionalization process allows the bubbles to selectively bind to the desired cells.

  2. Cell Binding: The functionalized glass bubbles are introduced into the biological sample containing the cell mixture. The bubbles selectively bind to the target cells based on the specific interactions between the functionalized surface and the cell's receptors or antigens.

  3. Separation and Recovery: After binding to the target cells, the glass bubbles, now carrying the desired cells, can be separated from the rest of the sample using various methods such as centrifugation, filtration, or magnetic separation techniques. Once isolated, the cells attached to the glass bubbles can be recovered by removing them from the surface of the bubbles using specific treatments or dissociation methods.

  4. Purity and Viability Assessment: The recovered cells may undergo further analysis to assess their purity and viability. This step ensures that the isolated cells are suitable for subsequent experiments or applications.

The use of glass bubbles in cell isolation and recovery processes offers several advantages:

The application of glass bubbles for cell isolation is a part of ongoing research and development in the field of biotechnology and biomedical sciences. Techniques involving glass bubbles continue to evolve, offering promising advancements in cell separation, sorting, and isolation, with potential applications in regenerative medicine, diagnostics, and therapeutic development.