Hollow glass microspheres (HGMs) are not generally considered harmful to human health. They are small, lightweight particles made of glass, typically ranging in size from 1 to 100 microns in diameter. HGMs are commonly used as a lightweight filler material in a variety of applications, including paints, coatings, adhesives, and composites.

Several studies have evaluated the potential health effects of exposure to HGMs, and the results have generally been reassuring. The available evidence suggests that HGMs are not likely to cause significant harm to human health when used as intended.

Inhalation is the primary route of exposure to HGMs, and studies have shown that the particles are generally not respirable, meaning they are too large to enter the lungs and cause damage. Some studies have reported minor respiratory effects in animals exposed to high levels of HGMs, but these effects were generally reversible and not considered significant.

There is also no evidence to suggest that HGMs are absorbed into the body through the skin or gastrointestinal tract, as they are inert and do not react with biological tissues.

That being said, like with any material, it is important to handle HGMs safely and in accordance with applicable regulations. Manufacturers of HGMs typically provide guidelines for safe handling, storage, and disposal of their products, and it is important to follow these guidelines to minimize the potential for exposure and ensure safe use.